Bongertz Vera, Ouverney Elaine Priscilla, Teixeira Sylvia L M, Silva-de-Jesus Carlos, Hacker Mariana A, Morgado Mariza G, Bastos Francisco I
Laborat rio de Aids e Imunologia Molecular, Departamento de Imunologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brasil.
Mem Inst Oswaldo Cruz. 2003 Mar;98(2):209-12. doi: 10.1590/s0074-02762003000200007. Epub 2003 May 15.
Sera from infected injection drug users (IDU) have shown to have antibodies against synthetic human immunodeficiency virus-1 (HIV-1) envelope peptides more frequently. In this study, reactivity of 48 IDU plasma were compared to 60 plasmas obtained from sexually infected individuals (S). The overall reactivity of plasma from IDU compared to S was higher, and the reactivity titers were much higher for IDU plasma than S. IDU plasma also showed a broader antibody response. The higher reactivity titers were observed mainly for the gp41 immunodominant epitope and V3 peptides corresponding to the consensus sequences of HIV-1 subtypes/variants prevalent in Brazil (B, F, C) indicating the specificity in the higher immune response of IDU.
来自受感染注射吸毒者（IDU）的血清已显示更频繁地含有针对合成人类免疫缺陷病毒1型（HIV-1）包膜肽的抗体。在本研究中，将48名注射吸毒者的血浆反应性与60名性传播感染者（S）的血浆进行了比较。与S相比，注射吸毒者血浆的总体反应性更高，且注射吸毒者血浆的反应滴度比S高得多。注射吸毒者血浆还表现出更广泛的抗体反应。主要在gp41免疫显性表位和与巴西流行的HIV-1亚型/变体（B、F、C）的共有序列相对应的V3肽中观察到较高的反应滴度，这表明注射吸毒者较高免疫反应具有特异性。
