β受体阻滞剂治疗对充血性心力衰竭患者P波时限及离散度的长期影响：一种新效应？
Long-term effects of beta blocker therapy on P-wave duration and dispersion in congestive heart failure patients: a new effect?
作者信息
Camsari Ahmet, Pekdemir Hasan, Akkus M Necdet, Yenihan Senay, Döven Oben, Cin V Gökhan
机构信息
Cardiology Department, Mersin University Faculty of Medicine, Mersin, Turkey.
出版信息
J Electrocardiol. 2003 Apr;36(2):111-6. doi: 10.1054/jelc.2003.50020.
Atrial fibrillation (AF) is associated with heart failure in approximately 20%-50% of patients with increased morbidity and mortality. P-wave maximum duration (PWM) and P-wave dispersion (PWD) are recent ECG markers and reflect increased risk of AF. The aim of our study was to investigate the long-term effects of metoprolol on atrial conduction abnormalities as estimated by PWM and PWD, which were calculated on 12-derivation surface ECG in heart failure patients. Forty-two NYHA class 3 to 4 patients (23 males, 19 females and aged 52.9 +/- 11.2) were enrolled in the study. At the end of the 6 months, PWM and PWD values were significantly decreased (for PWM: from 115.2 +/- 12.6 to 105.4 +/- 13.5; for PWD: from 39.3 +/- 9.1 to 28.6 +/- 10.5; P <.001 for both). Metoprolol treatment is associated with a decreased duration of PWM and PWD and this may reflect a reduction in the probability of atrial fibrillation in heart failure patients.
在大约20%-50%的患者中，心房颤动（AF）与心力衰竭相关，发病率和死亡率增加。P波最大时限（PWM）和P波离散度（PWD）是最近的心电图标志物，反映了房颤风险的增加。我们研究的目的是调查美托洛尔对心房传导异常的长期影响，通过PWM和PWD评估，这两者是在心力衰竭患者的12导联体表心电图上计算得出的。42名纽约心脏协会（NYHA）3至4级患者（23名男性，19名女性，年龄52.9±11.2岁）被纳入研究。在6个月末，PWM和PWD值显著降低（PWM：从115.2±12.6降至105.4±13.5；PWD：从39.3±9.1降至28.6±10.5；两者P均<.001）。美托洛尔治疗与PWM和PWD持续时间的降低相关，这可能反映了心力衰竭患者房颤发生概率的降低。
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