Chi F, Wang Z, Li K
Hearing Laboratory of Ministry of Hygiene, Eye Ear Nose & Throat Hospital of Shanghai Medical University, Shanghai 200031.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1999 Feb;34(1):11-3.
To investigate the calcitonin gene-related peptide (CGRP) effect on efferent vestibular system during pathological state of vestibular afferent system.
An animal model of vestibular compensation was made by administration of streptomycin to rat vestibular organ to destroy unilateral vestibular function. Change of CGRP in efferent vestibular neurons in all processes from vestibular disorder to vestibular compensation was observed utilizing ABC method of immunohistochemical technique.
Efferent vestibular neurons of normal animals showed low immunoreactivity to CGRP. The number of CGRP immunoreactivity neurons and level of CGRP immunoreactivity increased in efferent vestibular system during vestibular disorder, and these changes decreased with vestibular compensation.
Activity of CGRP in efferent vestibular system plays a regular role on accelerating vestibular compensation.
研究降钙素基因相关肽（CGRP）在前庭传入系统病理状态下对传出前庭系统的影响。
通过向大鼠前庭器官注射链霉素破坏单侧前庭功能，建立前庭代偿动物模型。利用免疫组织化学技术的ABC法观察从前庭紊乱到前庭代偿全过程中传出前庭神经元中CGRP的变化。
正常动物的传出前庭神经元对CGRP显示低免疫反应性。在前庭紊乱期间，传出前庭系统中CGRP免疫反应性神经元的数量和CGRP免疫反应性水平增加，且这些变化随着前庭代偿而降低。
传出前庭系统中CGRP的活性在加速前庭代偿中发挥规律性作用。
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