Ohno K, Takeda N, Tanaka-Tsuji M, Matsunaga T
Department of Otolaryngology, Osaka University Medical School, Japan.
Acta Otolaryngol Suppl. 1993;501:16-20. doi: 10.3109/00016489309126206.
Many calcitonin gene-related peptide-like immunoreactive (CGRP-IR) fibers were found in the vestibular end-organs and the cochlea of rats. CGRP-IR fibers in the vestibular end-organs originated in the bilateral cell groups dorsolateral to the genu of the facial nerve. These fibers formed a fiber plexus at the base of the sensory epithelia in the maculae of the otolith organs and the ampullae of the semicircular canals, and formed synaptic contacts with the nerve chalice on type I vestibular sensory cells. CGRP-IR fibers in the cochlea originated in the ipsilateral lateral superior olivary nucleus. Most of them existed in the inner spiral bundle under the inner hair cells, and formed synaptic contacts with afferent terminals on the inner hair cells. These findings suggest a postsynaptic modulation of CGRP on the vestibular and cochlear information at the level of type I vestibular sensory cells and the inner hair cells.
在大鼠的前庭终器和耳蜗中发现了许多降钙素基因相关肽样免疫反应性（CGRP-IR）纤维。前庭终器中的CGRP-IR纤维起源于面神经膝状节背外侧的双侧细胞群。这些纤维在耳石器官的黄斑和半规管壶腹的感觉上皮底部形成纤维丛，并与I型前庭感觉细胞上的神经杯形成突触联系。耳蜗中的CGRP-IR纤维起源于同侧外侧上橄榄核。它们大多存在于内毛细胞下方的内螺旋束中，并与内毛细胞上的传入终末形成突触联系。这些发现提示CGRP在I型前庭感觉细胞和内毛细胞水平对前庭和耳蜗信息具有突触后调制作用。
