Barnes Edward, Khan Masood A
Department of Cardiology, Great Western Hospital, Swindon, UK.
Heart Fail Rev. 2003 Apr;8(2):155-60. doi: 10.1023/a:1023092702389.
Myocardial stunning refers to the contractile dysfunction that occurs following an episode of acute ischaemia, despite the return of normal blood flow. The phenomenon was initially identified in animal models, where it has been very well characterised, and there was initial doubt about whether a similar syndrome occurred in humans, and if it did, whether it was of any clinical relevance. This article outlines the conditions that must be met to diagnose myocardial stunning and why it has been difficult to confirm its presence in humans. The clinical scenarios where it has now been clearly identified and those others where it may also occur and be of clinical importance are also reviewed.
心肌顿抑是指急性缺血发作后出现的收缩功能障碍,尽管血流已恢复正常。这一现象最初是在动物模型中发现的,在该模型中已得到充分的特征描述,最初人们怀疑人类是否也存在类似综合征,以及即便存在,它是否具有临床相关性。本文概述了诊断心肌顿抑必须满足的条件,以及为何难以在人类中证实其存在。文中还回顾了现已明确发现心肌顿抑的临床情况,以及其他可能出现且具有临床意义的情况。