Ghosh B, Mittal S, Kumar S, Dadhwal V
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.
Int J Gynaecol Obstet. 2003 Jun;81(3):267-71. doi: 10.1016/s0020-7292(03)00124-3.
To determine normal level of nucleated red blood cells (NRBC) per 100 white blood cells (WBC) in cord blood of term non-asphyxiated newborns and to investigate variations in NRBC counts in perinatal asphyxia.
A total of 75 cases were studied. Levels of NRBC per 100 WBC in umbilical venous blood were compared between 26 asphyxiated newborns (group I) and 49 non-asphyxiated newborns (group II). Correlation with neonatal outcome was also evaluated.
The mean (+/-S.D.) NRBC per 100 WBC level in umbilical blood of newborns in group I was 16.5+/-6.4, range 3-25; whereas that in group II was 8.6+/-7.01, range 1-26. This difference was statistically significant (P<0.001). A statistically significant negative correlation existed between NRBC level and markers of acute intrapartum asphyxia, Apgar score and umbilical arterial pH (r=-0.50, P<0.001 and r=-0.48, P<0.001, respectively). Positive correlation was demonstrated with evidence of chronic antepartum asphyxia, presence of pregnancy induced hypertension and intrauterine growth restriction (r=2.66, P=0.02). A high NRBC count in umbilical blood correlated with poor early neonatal outcome.
The level of NRBC per 100 WBC correlates both with acute as well as chronic antepartum asphyxia. Further, it can be used as a reliable index of early neonatal outcome.
确定足月非窒息新生儿脐带血中每100个白细胞（WBC）中含有的有核红细胞（NRBC）的正常水平，并研究围产期窒息时NRBC计数的变化。
共研究75例病例。比较了26例窒息新生儿（I组）和49例非窒息新生儿（II组）脐静脉血中每100个WBC的NRBC水平。还评估了其与新生儿结局的相关性。
I组新生儿脐血中每100个WBC的NRBC平均水平（±标准差）为16.5±6.4，范围为3 - 25；而II组为8.6±7.01，范围为1 - 26。这种差异具有统计学意义（P<0.001）。NRBC水平与急性产时窒息标志物、阿氏评分和脐动脉pH值之间存在统计学意义的负相关（r = -0.50，P<0.001；r = -0.48，P<0.001）。与慢性产前窒息证据、妊娠高血压综合征和宫内生长受限呈正相关（r = 2.66，P = 0.02）。脐血中NRBC计数高与早期新生儿结局不良相关。
每100个WBC的NRBC水平与急性和慢性产前窒息均相关。此外，它可作为早期新生儿结局的可靠指标。
