Cross-reactivity of HLA-B*1801-restricted T-lymphocyte clones with target cells expressing variants of the human cytomegalovirus 72kDa-IE1 protein.
作者信息
Prod'homme Virginie, Retière Christelle, Valtcheva Ralitza, Bonneville Marc, Hallet Marie-Martine
机构信息
Institut National de la Santé et de la Recherche Médicale U463, Institut de Biologie, 44093 Nantes Cedex 1, France.
出版信息
J Virol. 2003 Jun;77(12):7139-42. doi: 10.1128/jvi.77.12.7139-7142.2003.
Abstract
The impact of natural polymorphism in a cytomegalovirus-dominant HLA-B(*)1801-restricted epitope, IE1(199-206), on the specific responses of T-cell clones was assessed by measuring their cytolytic activity against target cells expressing mutated recombinant IE1 proteins. Our results suggest an in vivo selection of T lymphocytes that cross-react with multiple IE1 variants.
摘要
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