Yatabe Yoshihisa, Miyakawa Shumpei, Miyazaki Teruo, Matsuzaki Yasushi, Ochiai Naoyuki
Department of Orthopaedic Surgery, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8575, Japan.
J Orthop Sci. 2003;8(3):415-9. doi: 10.1007/s10776-002-0636-1.
To investigate the effects of taurine administration on exercise, we studied taurine concentrations in rat skeletal muscles after endurance running and the duration of running time to exhaustion, with and without taurine administration. For study 1 we divided 40 male SD rats into two groups: endurance exercise group ( n = 20) and sedentary control group ( n = 20). Each was further divided into two groups; one received distilled water ( n = 10) and the other taurine solution in water 0.5 g/kg/day orally ( n = 10) for 2 weeks. The exercise group performed treadmill running (60 min) once only after their nursing period. For study 2, we divided 10 male SD rats into two groups; one ( n = 5) received taurine 0.5 g/kg/day, and the other ( n = 5) received no taurine for 2 weeks; the two groups then performed treadmill running to exhaustion. In study 1, taurine administration increased taurine concentrations in leg skeletal muscles, whereas the concentrations were significantly lower in the exercised groups without taurine administration. Taurine administration reduced the decrease in taurine concentration in skeletal muscles on exercise. In study 2, the duration of running time to exhaustion was significantly increased by taurine administration. We concluded that peroral administration of taurine maintains the taurine concentration in skeletal muscle on exercise and up-regulates physical endurance.
为了研究补充牛磺酸对运动的影响，我们研究了在耐力跑前后以及补充或不补充牛磺酸的情况下，大鼠骨骼肌中牛磺酸的浓度，以及力竭跑步时间的持续时间。在研究1中，我们将40只雄性SD大鼠分为两组：耐力运动组（n = 20）和久坐对照组（n = 20）。每组再进一步分为两组；一组给予蒸馏水（n = 10），另一组口服0.5 g/kg/天的牛磺酸水溶液（n = 10），持续2周。运动组在哺乳期结束后仅进行一次跑步机跑步（60分钟）。在研究2中，我们将10只雄性SD大鼠分为两组；一组（n = 5）给予0.5 g/kg/天的牛磺酸，另一组（n = 5）在2周内不给予牛磺酸；然后两组进行跑步机跑步直至力竭。在研究1中，补充牛磺酸可提高腿部骨骼肌中牛磺酸的浓度，而未补充牛磺酸的运动组中牛磺酸浓度显著较低。补充牛磺酸可减少运动时骨骼肌中牛磺酸浓度的下降。在研究2中，补充牛磺酸显著延长了力竭跑步时间。我们得出结论，口服牛磺酸可在运动时维持骨骼肌中的牛磺酸浓度，并上调身体耐力。
