Zeng Z, Chen F, Zhang Q, Yang A, Zeng X, Cheng W, Guo Z, Xu G
Department of Head and Neck Surgery, Cancer Center, Sun Yatsen University of Medical Sciences, Guangzhou 510060, China.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2000 Feb;35(1):32-4.
To investigate the effect of radiotherapy in the combined treatment of laryngeal cancer with partial laryngectomy.
One hundred and seventy-one cases of laryngeal cancer were randomly separated into three groups of partial laryngectomy, partial laryngectomy with preoperative radiotherapy (dose 40-50Gy) and partial laryngectomy with postoperative radiotherapy(dose 51-70 Gy). The surgical procedures included cordectomy, vertical partial laryngectomy, horizontal partial laryngectomy and near total laryngectomy.
The overall 5-year survival rate was 82% (123/150). The 5-year survival rates for surgery alone group (56 cases), surgery with preoperative radiotherapy group(65 cases) and surgery with postoperative radiotherapy group(50 cases) were 85.7%, 80.7% and 79.5% respectively. There was no significant difference among the groups(chi 2 = 0.703, P = 0.704). Analysis of survival rates revealed a significant difference among the different stages(chi 2 = 12.248, P = 0.007). All 171 cases except 3 that had near total laryngectomy achieved satisfactory phonation.
Neither preoperative radiotherapy nor postoperative radiotherapy can improve the 5-year survival rate of laryngeal cancer with partial laryngectomy. All patients with partial laryngectomy got satisfactory phonation.
探讨放射治疗在喉癌部分喉切除术综合治疗中的作用。
将171例喉癌患者随机分为单纯部分喉切除术组、术前放疗（剂量40 - 50Gy）后行部分喉切除术组和术后放疗（剂量51 - 70Gy）后行部分喉切除术组。手术方式包括声带切除术、垂直部分喉切除术、水平部分喉切除术和近全喉切除术。
5年总生存率为82%（123/150）。单纯手术组（56例）、术前放疗后手术组（65例）和术后放疗后手术组（50例）的5年生存率分别为85.7%、80.7%和79.5%。各组间差异无统计学意义（χ2 = 0.703，P = 0.704）。生存率分析显示不同分期间差异有统计学意义（χ2 =12.248，P = 0.007）。除3例行近全喉切除术的患者外，其余171例患者发声均满意。
术前放疗和术后放疗均不能提高喉癌部分喉切除术患者的5年生存率。所有部分喉切除术患者发声均满意。
