[Effects of microcirculatory disorders of inner ear on blood-labyrinth barrier permeability in guinea pigs].

OBJECTIVE

To study the changes of blood-labyrinth barrier permeability during cochlea microcirculatory disorders in guinea pigs.

METHODS

Using modified method of Evan's blue fluorescence, the changes of permeability of blood-labyrinth barrier were observed in the animal model of cochlea microcirculatory disorders which was induced by photochemical reaction.

RESULTS

Amount of Evan's blue passing through the blood-labyrinth barrier was (1.709 +/- 0.769) microgram per guinea pig after 2 hours and (2.849 +/- 0.653) microgram per guinea pig after 4 hours when the cochlea was in microcirculatory disorder.

CONCLUSION

The results indicated that the permeability of blood-labyrinth barrier increased when cochlea microcirculatory disorders occurred and the increase of blood-labyrinth barrier permeability may be one of the important mechanisms which causes the cochlear ischemic lesions.