对狗急性给予利血平后冠状动脉交感缩血管作用的揭示。
Unmasking of sympathetic vasoconstruction of the coronary vessels after acute administration of reserpine to dogs.
作者信息
Szentiványi M, Kunos G, Juhász-NAGY A
出版信息
Can J Physiol Pharmacol. 1976 Apr;54(2):166-9. doi: 10.1139/y76-027.
DOI:10.1139/y76-027
PMID:1276989
Abstract
Acute intravenous administration of reserpine or pretreatment of dogs with Segontin selectively abolished coronary vasodilation and unmasked a constrictor response to stimulation of the cardiac sympathetics. In view of earlier findings of separate coronary vasomotor and cardiostimulatory sympathetic innervation, the results are interpreted to indicate the existence of reserpine-resistant short (vasomotor) and reserpine-sensitive long (cardiostimulatory) sympathetic postganglionic neurons.
摘要
急性静脉注射利血平或用赛庚啶预处理犬，可选择性地消除冠脉血管舒张，并揭示出刺激心脏交感神经时的收缩反应。鉴于早期关于冠脉血管运动和心脏刺激交感神经支配分离的研究结果，这些结果被解释为表明存在利血平抵抗的短（血管运动）和利血平敏感的长（心脏刺激）交感神经节后神经元。
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