子宫内膜异位症患者淋巴细胞亚群的免疫学与内分泌学研究及不孕症的医学治疗

Immunological and endocrinological studies on lymphocyte subpopulation and medical treatment for infertility in patients with endometriosis.

作者信息

Furuya Kenichi, Murakami Mitsutaka, Makimura Noriko, Matsuda Hideo, Ikou Kanoko, Saito Keiko, Kawakami Yuichi, Shibazaki Tomoko, Fukui Utako, Mizumoto Yoshifumi, Tokuoka Susumu, Nagata Ichiro, Kikuchi Yoshihiro

机构信息

Department of Obstetrics and Gynecology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.

出版信息

Mol Cell Endocrinol. 2003 Apr 28;202(1-2):195-9. doi: 10.1016/s0303-7207(03)00083-2.

DOI:10.1016/s0303-7207(03)00083-2

PMID:12770751

Abstract

We investigated the relationship between interleukin-6 (IL-6) levels and subset profiles of T lymphocyte (T-cell) and macrophage in peritoneal fluid (PF) with or without endometriosis (EM). IL-6 levels in PF with EM were significantly higher than those without EM. IL-6 producing cells with EM were analyzed in each activated mature T-cell (CD3+CD69+) and macrophage (CD14+) were 0.5 and 3.5%, respectively, whereas it was mostly negative in those without EM. Cytotoxic T-cell (CD8+CD11b-) profiles in PF with EM were also quiet different from those without EM. Cellular immunity in the peripheral blood did not change during the course of IVF-ET cycles, although plasma levels of ovarian steroid hormones significantly increased comparing with that in normal ovarian cycles. Cytotoxic T-cell type 1 (Tc1) profiles might be useful predictive values in the pregnancy outcome for infertile patients with EM.

摘要

我们研究了伴有或不伴有子宫内膜异位症（EM）的腹膜液（PF）中白细胞介素-6（IL-6）水平与T淋巴细胞（T细胞）及巨噬细胞亚群分布之间的关系。伴有EM的PF中IL-6水平显著高于不伴有EM的情况。对伴有EM的IL-6产生细胞进行分析，在每个活化的成熟T细胞（CD3+CD69+）和巨噬细胞（CD14+）中分别为0.5%和3.5%，而在不伴有EM的细胞中大多为阴性。伴有EM的PF中细胞毒性T细胞（CD8+CD11b-）分布也与不伴有EM的情况有很大不同。尽管与正常卵巢周期相比，体外受精-胚胎移植（IVF-ET）周期中血浆卵巢甾体激素水平显著升高，但外周血中的细胞免疫在IVF-ET周期过程中并未改变。1型细胞毒性T细胞（Tc1）分布可能对患有EM的不孕患者的妊娠结局具有预测价值。