Diversity within the DRB1*08 allele family in four populations from a United States hematopoietic stem cell donor database and characterization of five novel DRB1*08 alleles.

Diversity within the DRB108 allele family in four populations from a United States hematopoietic stem cell donor database and characterization of five novel DRB108 alleles.

作者信息

Rizzuto Gabrielle, Li Li, Steiner Noriko, Slack Rebecca, Tang Ting, Heine Uwe, Lin Yu Su, Ng Jennifer, Hartzman RobertJ, Hurley Carolyn Katovich

机构信息

Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.

出版信息

Hum Immunol. 2003 Jun;64(6):607-13. doi: 10.1016/s0198-8859(03)00069-7.

DOI:10.1016/s0198-8859(03)00069-7

PMID:12770791

Abstract

The frequencies of DRB108 alleles within four major United States populations found within a hematopoietic stem cell volunteer donor database were determined by DNA sequencing of over 60 DRB108 positive individuals from each group. Seven of 30 known DRB108 alleles were identified within this study population (080101, 080201, 080302, 080401, 0806, 0807, and 0811). Each ethnic group was characterized by a different highly prevalent allele: DRB1080101 in Caucasians; DRB1080401 in African-Americans; DRB1080302 in Asians; and DRB1080201 in Hispanics. The alleles DRB1080101, DRB1080201, and DRB1080401 were present in all four populations. This report also describes five novel DRB1*08 alleles uncovered during routine human leukocyte antigen typing.

摘要