美国四个群体中HLA-DRB1*02等位基因的多样性有限以及DRB1-DRB5单倍型关联

Limited diversity of HLA-DRB1*02 alleles and DRB1-DRB5 haplotype associations in four United States population groups.

作者信息

Baldassarre L A, Steiner N K, Jones P, Tang T, Slack R, Ng J, Hartzman R J, Hurley C K

机构信息

Department of Oncology, Department of Pediatrics, Georgetown University Medical Center, 3870 Reservoir Road NW, Washington, DC 20057, USA.

出版信息

Tissue Antigens. 2003 Mar;61(3):249-52. doi: 10.1034/j.1399-0039.2003.00018.x.

DOI:10.1034/j.1399-0039.2003.00018.x

PMID:12694574

Abstract

At least 60 DRB102 positive individuals from each of four US population groups found within a hematopoietic stem cell volunteer donor registry - Caucasoids, African Americans, Asians/Pacific Islanders, and Hispanics - were randomly selected from a database of 82,979 individuals. DRB102 alleles were identified by DNA sequencing. A total of five of 23 known DRB102 alleles were detected. DRB115011 was the predominant DRB102 allele in Caucasoids and Hispanics. The most common DRB102 allele observed in African Americans was DRB11503, and DRB115021 in Asians/Pacific Islanders. Caucasoids were found to be the least diversified; only DRB115011 and DRB116011 were observed. A subset of individuals was also typed for DRB5 alleles by DNA sequencing. DRB501011, DRB50102, DRB50103, DRB50108N and DRB5*0202 were detected and nine DRB1-DRB5 haplotypes defined.

摘要

在美国造血干细胞志愿捐献者登记处的四个美国人群组（白种人、非裔美国人、亚裔/太平洋岛民和西班牙裔）中，从82979人的数据库中随机挑选出至少60名DRB102阳性个体。通过DNA测序鉴定DRB102等位基因。在23个已知的DRB102等位基因中共检测到5个。DRB115011是白种人和西班牙裔中主要的DRB102等位基因。在非裔美国人中观察到的最常见的DRB102等位基因是DRB11503，在亚裔/太平洋岛民中是DRB115021。发现白种人的多样性最低；仅观察到DRB115011和DRB116011。还通过DNA测序对一部分个体进行了DRB5等位基因分型。检测到DRB501011、DRB50102、DRB50103、DRB50108N和DRB5*0202，并定义了9种DRB1-DRB5单倍型。