干扰素β和静脉注射免疫球蛋白对中枢和周围脱髓鞘儿童的不同作用。

Contrasting effects of IFNbeta and IVIG in children with central and peripheral demyelination.

作者信息

Pirko I, Kuntz N L, Patterson M, Keegan B M, Weinshenker B G, Rodriguez M

机构信息

Department of Neurology, Mayo Clinic, Rochester, MN 55902, USA.

出版信息

Neurology. 2003 May 27;60(10):1697-9. doi: 10.1212/01.wnl.0000064163.94122.eb.

DOI:10.1212/01.wnl.0000064163.94122.eb

PMID:12771272

Abstract

Reported are three children with MS who responded dramatically to interferon-beta (IFNbeta) therapy. While on immunomodulatory therapy, they developed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that responded to IV immunoglobulin (IVIG) administration. These cases emphasize two interesting observations: 1) IFNbeta treatment did not prevent development of CIDP; 2) CIDP in the context of MS responded to IVIG, even though IVIG had no therapeutic effect on the central demyelinating disease.

摘要

报告了三名患有多发性硬化症（MS）的儿童，他们对β-干扰素（IFNβ）治疗反应显著。在接受免疫调节治疗期间，他们患上了慢性炎症性脱髓鞘性多发性神经根神经病（CIDP），对静脉注射免疫球蛋白（IVIG）治疗有反应。这些病例强调了两个有趣的观察结果：1）IFNβ治疗未能预防CIDP的发生；2）MS背景下的CIDP对IVIG有反应，尽管IVIG对中枢性脱髓鞘疾病没有治疗效果。