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The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1.
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The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of Mcl-1 through a PI 3-K/Akt pathway.
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Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.
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Generation of polyclonal plasmablasts from peripheral blood B cells: a normal counterpart of malignant plasmablasts.
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Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.
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Overexpression of Mcl-1 in anaplastic large cell lymphoma cell lines and tumors.
Am J Pathol. 2002 Jun;160(6):2309-10. doi: 10.1016/S0002-9440(10)61178-9.
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Increased MCL-1 expression is associated with poor prognosis in ovarian carcinomas.
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MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis.
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Myeloid cell factor-1 is a critical survival factor for multiple myeloma.
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Novel evidence of a role for chromosome 1 pericentric heterochromatin in the pathogenesis of B-cell lymphoma and multiple myeloma.
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Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis.
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Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils.
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