Benazzi Franco
Department of Psychiatry, National Health Service, Via Pozzetto 17, 48015 Castiglione di Cervia RA, Italy.
Curr Psychiatry Rep. 2003 Jul;5(3):192-6. doi: 10.1007/s11920-003-0041-1.
The aim of this review is to find data about the outcome of schizophreniform disorder. As different definitions of schizophreniform disorder were found in the literature, it was not surprising that data on its outcome, and on the relationship of schizophreniform disorder to schizophrenia and to mood disorders (as this relationship is linked to outcome), were often different and opposite. Its classic description of an acute onset psychotic episode with mood instability and a relatively brief duration should be the focus of future studies. Current studies, apart from a small number, lump together different (and probably distinct) subtypes of schizophreniform disorder (one with good prognostic features, and one without good prognostic features, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition). Studies of mixed samples led to different results, probably depending on the relative prevalence of one subtype over the other one. The few studies on schizophreniform disorder with good prognostic features found more often an episodic, recurrent course, and a family history of mood disorders. These features link this schizophreniform disorder subtype more to mood disorders than to schizophrenia. If confirmed by future studies, these preliminary findings can have very important treatment implications, given the very different treatment strategies in mood disorders compared with schizophrenia.
本综述的目的是查找有关精神分裂症样障碍预后的数据。由于文献中发现了精神分裂症样障碍的不同定义，因此其预后数据以及精神分裂症样障碍与精神分裂症和心境障碍的关系（因为这种关系与预后相关）往往不同且相反也就不足为奇了。其关于急性起病的精神病性发作伴情绪不稳定且病程相对短暂的经典描述应成为未来研究的重点。目前的研究，除少数外，将精神分裂症样障碍的不同（且可能不同）亚型归为一类（根据《精神障碍诊断与统计手册》第四版，一种具有良好预后特征，另一种没有良好预后特征）。对混合样本的研究得出了不同的结果，这可能取决于一种亚型相对于另一种亚型的相对患病率。少数关于具有良好预后特征的精神分裂症样障碍的研究更常发现其病程呈发作性、复发性，且有心境障碍家族史。这些特征将这种精神分裂症样障碍亚型与心境障碍的联系比与精神分裂症的联系更为紧密。如果未来的研究证实了这些初步发现，鉴于心境障碍与精神分裂症的治疗策略截然不同，这些发现可能会对治疗产生非常重要的影响。
