[链霉菌——聚酮类抗生素的生产者]

[Streptomycetes--producers of polyketide antibiotics].

作者信息

Matseliukh A B

机构信息

Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, 154 Zabolotny St., Kyiv, 03143, Ukraine.

出版信息

Mikrobiol Z. 2003 Jan-Apr;65(1-2):168-81.

PMID:12774508

Abstract

The review is dedicated to biosynthesis of polyketides compounds by streptomycetes. It contains new data about structure of streptomycete chromosome, structure and action mechanism of polyketidesynthases of I and II types and gene clusters determining the biosynthesis of polyketides. A new promising approach is considered--the combinatorial biosynthesis of hybrid "unnatural" antibiotics by means of gene engineering construction of recombinant strains bearing the biosynthetic genes of bacterial aromatic polyketidesynthases.

摘要

这篇综述致力于链霉菌合成聚酮化合物的生物合成过程。它包含了关于链霉菌染色体结构、I型和II型聚酮合酶的结构及作用机制以及决定聚酮生物合成的基因簇的新数据。文中还探讨了一种新的有前景的方法——通过构建携带细菌芳香族聚酮合酶生物合成基因的重组菌株，利用基因工程手段进行杂交“非天然”抗生素的组合生物合成。