Grant C, Routh J I, Lawton W, Witte D L
Clin Chim Acta. 1976 Jun 1;69(2):333-40. doi: 10.1016/0009-8981(76)90513-1.
Circulating dopamine beta-hydroxylase levels and norepinephrine excretion were measured in 76 mild hypertensive patients. Levels of dopamine beta-hydroxylase, norepinephrine excretion and blood pressure were obtained both before and after the initiation of therapy. Data from 20 patients exhibiting a diastolic blood pressure decrease of 10 mmHg or more were compared with data from 10 normotensive individuals. Changes in dopamine beta-hydroxylase levels were similar for the two groups and were not related to blood pressure changes. Intra-individual variation was small in both groups. There were no detectable functional relationships between diastolic pressure and urinary norepinephrine, norepinephrine and dopamine beta-hydroxylase or dopamine beta-hydroxylase and diastolic pressure. It dose not seem likely that dopamine beta-hydroxylase levels can replace urinary catecholamines as a commonly used index of sympathetic activity.
对76例轻度高血压患者测定了循环多巴胺β-羟化酶水平和去甲肾上腺素排泄量。在开始治疗前后均获取了多巴胺β-羟化酶水平、去甲肾上腺素排泄量和血压数据。将舒张压下降10mmHg或更多的20例患者的数据与10例血压正常个体的数据进行了比较。两组多巴胺β-羟化酶水平的变化相似，且与血压变化无关。两组个体内差异均较小。舒张压与尿去甲肾上腺素、去甲肾上腺素与多巴胺β-羟化酶或多巴胺β-羟化酶与舒张压之间均未检测到功能关系。多巴胺β-羟化酶水平似乎不太可能取代尿儿茶酚胺作为常用的交感神经活动指标。
