Malumbres Marcos, Barbacid Mariano
Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas, Melchor Fernández Almagro 3, 28029 Madrid, Spain.
Nat Rev Cancer. 2003 Jun;3(6):459-65. doi: 10.1038/nrc1097.
From the pioneering work with acute transforming retroviruses to the current post-genomic era, RAS genes have always been at the leading edge of signal transduction and molecular oncology. Yet, a complete understanding of RAS function and dysfunction - mainly in human cancer - is still to come. The knowledge that has accumulated since their discovery 30 years ago has, however, been remarkable, and should pave the way for not only solving the outstanding issues regarding RAS biology, but also for developing efficacious drugs that could have a significant impact on cancer treatment.
从急性转化逆转录病毒的开创性研究到当前的后基因组时代，RAS基因一直处于信号转导和分子肿瘤学的前沿。然而，要全面了解RAS的功能和功能失调——主要是在人类癌症中——仍有待时日。自30年前发现RAS基因以来积累的知识堪称显著，这不仅应为解决有关RAS生物学的突出问题铺平道路，也为开发可能对癌症治疗产生重大影响的有效药物奠定基础。
