Natl Toxicol Program Tech Rep Ser. 1982 Jun;231:1-149.
Stannous chloride is an inorganic tin compound used as a food preservative, a stabilizer for colors, perfumes, and soaps, and as a reducing agent in tin plating. It is also used as a mordant in printing, a silvering agent for glass and plastics, a catalyst for curing phenolic resins, an additive to drilling muds, and an antisludge agent for oils. The chronic phase of a carcinogenesis bioassay for stannous chloride was conducted by feeding diets containing 1,000 or 2,000 ppm stannous chloride to groups of 50 F344/N rats and 50 B6C3F1/N mice of each sex for 105 weeks. Similar groups of untreated rats and mice served as controls. In this study, the concentrations of tin in bone, kidney, and liver were no higher than those attained in other lifetime studies utilizing 1/100 of the dose, suggesting that organ accumulation of tin was not dose dependent, but probably limited by absorption. Mean body weight gain and feed consumption of dosed and control rats and mice were comparable. Survival of high-dose male rats was somewhat lower than that of the control and low-dose groups (37/50, control; 39/50, low-dose; 30/50, high-dose). Survival of control male mice was less (P<0.05) than that of either dosed group (32/50, 42/50, 45/50); survival of the female mice appeared to be dose related (38/50, 33/50, 28/50). C-cell adenomas of the thyroid (2/50, 9/49, 5/50), C-cell adenomas or carcinomas combined (2/50, 13/49, 8/50), and adenomas of the lung (0/50, 0/50, 3/50) in male rats; and hepatocellular carcinomas or adenomas combined (3/49, 4/49, 8/49) and histiocytic malignant lymphomas (0/50, 0/49, 4/49) in female mice occurred with significant (P<0.05) positive trends and/or with significantly (P<0.05) increased incidences in the dosed groups when compared with the paired controls. However, when the lung adenomas in male rats are combined with lung carcinomas and when all lymphomas in female mice are considered, no statistical significance remains. For the thyroid C-cell tumors in male rats and for the liver tumors in female mice, the incidences in the high-dose groups were not significantly different from the historical control rates at that laboratory (C-cell tumors: 32/288, 11.1%; liver tumors: 24/297, 8%). When the historical control rate is used as a basis for comparison, the low-dose incidence of thyroid C-cell tumors remains significant (P<0.01). Under the conditions of this bioassay, stannous chloride was judged not to be carcinogenic for male or female F344/N rats or B6C3F1/N mice, although C-cell tumors of the thyroid gland in male rats may have been associated with the administration of the test chemical. Levels of Evidence of Carcinogenicity: Male Rats: Equivocal Female Rats: Negative Male Mice: Negative Female Mice: Negative
氯化亚锡是一种无机锡化合物，用作食品防腐剂、色素、香料和肥皂的稳定剂，以及镀锡中的还原剂。它还用作印染媒染剂、玻璃和塑料的镀银剂、酚醛树脂固化催化剂、钻井泥浆添加剂和油类的抗淤渣剂。通过给每组50只F344/N大鼠和50只B6C3F1/N小鼠（雌雄各半）喂食含1000或2000 ppm氯化亚锡的饲料105周，进行了氯化亚锡致癌生物测定的慢性阶段研究。相似的未处理大鼠和小鼠组作为对照。在本研究中，骨、肾和肝中的锡浓度不高于其他使用1/100剂量的终生研究中所达到的浓度，这表明锡在器官中的蓄积不依赖于剂量，而可能受吸收限制。给药组和对照组大鼠及小鼠的平均体重增加和饲料消耗量相当。高剂量雄性大鼠的存活率略低于对照组和低剂量组（对照组37/50，低剂量组39/50，高剂量组30/50）。对照雄性小鼠的存活率低于（P<0.05）任一给药组（32/50、42/50、45/50）；雌性小鼠的存活率似乎与剂量有关（38/50、33/50、28/50）。雄性大鼠的甲状腺C细胞腺瘤（2/50、9/49、5/50）、C细胞腺瘤或癌合并（2/50、13/49、8/50）以及肺腺瘤（0/50、0/50、3/50）；雌性小鼠的肝细胞癌或腺瘤合并（3/49、4/49、8/49）和组织细胞性恶性淋巴瘤（0/50、0/49、4/49），与配对对照组相比，给药组出现显著（P<0.05）的阳性趋势和/或显著（P<0.05）增加的发生率。然而，当将雄性大鼠的肺腺瘤与肺癌合并，以及考虑雌性小鼠的所有淋巴瘤时，无统计学意义。对于雄性大鼠的甲状腺C细胞肿瘤和雌性小鼠的肝肿瘤，高剂量组的发生率与该实验室的历史对照率无显著差异（C细胞肿瘤：32/288，11.1%；肝肿瘤：24/297，8%）。以历史对照率为比较基础时，甲状腺C细胞肿瘤的低剂量发生率仍具有显著性（P<0.01）。在本生物测定条件下，尽管雄性大鼠的甲状腺C细胞肿瘤可能与受试化学品的给药有关，但判定氯化亚锡对雄性或雌性F344/N大鼠或B6C3F1/N小鼠无致癌性。致癌性证据水平：雄性大鼠：证据不明确；雌性大鼠：阴性；雄性小鼠：阴性；雌性小鼠：阴性
