Araujo Sergio Eduardo Alonso, Costa Adriana Furtado, Caravatto Pedro Paulo de Paris, Dumarco Rodrigo Blanco, Genzini Tércio, de Miranda Marcelo Perosa
Hospital Santa Helena, São Paulo, SP, Brasil.
Arq Gastroenterol. 2002 Jul-Sep;39(3):153-7. doi: 10.1590/s0004-28032002000300004. Epub 2003 May 21.
Indigo carmine dye is usually spread directly over the colon in many chromoscopic techniques aiming better visualization of a lesion already detected by conventional colonoscopy. Examination of the colon already stained by oral administration of indigo carmine dye may increase detection of small lesions resulting in higher sensibility of the colonoscopy in diagnosing diminutive lesions.
Analyze the results regarding the quality of chromoscopic technique and the indigo carmine dye distribution over the colon after oral administration.
Fifty patients undergoing colonoscopy were evaluated. A capsule containing 100 mg of indigo carmine dye was offered to these patients 30 min before oral mannitol prep routinely used. The indigo carmine dye contrast effect was graded as bad, regular or good according to preestablished criteria in three segments of the colon: right and left colon and the rectum.
In the right colon, good indigo carmine dye contrast effect was observed in only 9 (18.8%) patients, while it was considered regular and bad in 32 (66.6%) and in 7 (14.6%) patients, respectively. A good indigo carmine dye contrast effect was never observed in this series for the left colon or in the rectum. As a matter of fact, no indigo carmine dye was observed in the left colon in 80.9% and in the rectum in 92% of patients in this series.
Although it may be simple and desirable, oral administration of indigo carmine dye seems ineffective for enhancing detection of diminutive lesions by chromoscopy as result of poor colonic distribution of indigo carmine dye mainly at distal colonic sites.
在许多染色技术中，靛胭脂染料通常直接涂抹在结肠上，目的是更好地观察已通过传统结肠镜检查发现的病变。对口服靛胭脂染料染色后的结肠进行检查，可能会增加小病变的检出率，从而提高结肠镜检查诊断微小病变的敏感性。
分析口服靛胭脂染料后染色技术质量及染料在结肠内分布的结果。
对50例接受结肠镜检查的患者进行评估。在常规口服甘露醇准备前30分钟，给这些患者提供一粒含有100毫克靛胭脂染料的胶囊。根据预先设定的标准，将结肠的三个部分（右半结肠、左半结肠和直肠）的靛胭脂染料对比效果分为差、一般或好。
在右半结肠，仅9例（18.8%）患者观察到良好的靛胭脂染料对比效果，而分别有32例（66.6%）和7例（14.6%）患者的对比效果被认为一般和差。在本系列研究中，左半结肠或直肠从未观察到良好的靛胭脂染料对比效果。事实上，本系列中80.9%的患者左半结肠未观察到靛胭脂染料，92%的患者直肠未观察到靛胭脂染料。
尽管口服靛胭脂染料可能简单且理想，但由于靛胭脂染料在结肠内分布不佳，主要是在结肠远端部位，口服靛胭脂染料似乎无法有效增强染色技术对微小病变的检测。
