Guerra-Infante Fernando M, Carballo-Perea Raul, Zamora-Ruiz Angélica, López-Hurtado Marcela, Flores-Medina Saúl, Contreras Gustavo Miranda
Departamento de Infectología, Instituto Nacional de Perinatología, Montes Urales, México, DF, México.
Int J Fertil Womens Med. 2003 Mar-Apr;48(2):74-82.
To evaluate the clinical impact of the use of an indirect immunofluorescence assay (IFA) against Chlamydia as a method to identify patients with tubal factor infertility (TFI) in a population of infertile Mexican women.
This was a retrospective analysis made on 100 patients attending the infertility clinic who underwent laparoscopy. Blood and cervical samples were collected during the clinical examination. The presence of anti-Chlamydia trachomatis IgG antibodies was documented using the IFA test, and the presence of active chlamydial infection was evaluated using the nucleic acid hybridization assay.
The sensitivity and specificity values of the IFA test to identify patients with periadnexal adhesions were 45% and 82%, respectively; and the positive predictive and negative predictive values were 42% and 84%, and the positive and negative likelihood ratios were 2.5 and 0.7, respectively.
The IFA test was not usable for the identification of patients with periadnexal adhesions as a cause of infertility in this population. However, it could be useful as a screening test to decide which patients might receive laparoscopic treatment. Furthermore, it could be useful for identifying patients with active chlamydial infections in the upper genital tract, but a study with a larger sample needs to be done.
评估使用抗衣原体间接免疫荧光测定法（IFA）作为一种方法，以识别墨西哥不孕女性人群中输卵管因素不孕（TFI）患者的临床影响。
对100名在不孕不育诊所接受腹腔镜检查的患者进行回顾性分析。在临床检查期间采集血液和宫颈样本。使用IFA试验记录抗沙眼衣原体IgG抗体的存在，并使用核酸杂交试验评估衣原体活跃感染的存在。
IFA试验识别附件周围粘连患者的敏感性和特异性值分别为45%和82%；阳性预测值和阴性预测值分别为42%和84%，阳性似然比和阴性似然比分别为2.5和0.7。
在该人群中，IFA试验不可用于识别因附件周围粘连导致不孕的患者。然而，它作为一种筛查试验，对于决定哪些患者可能接受腹腔镜治疗可能是有用的。此外，它对于识别上生殖道衣原体活跃感染的患者可能是有用的，但需要进行更大样本量的研究。
