细胞生物化学中的分子图灵结构

Molecular Turing structures in the biochemistry of the cell.

作者信息

Hasslacher B., Kapral R., Lawniczak A.

机构信息

Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545Chemical Physics Theory Group, Department of Chemistry, University of Toronto, Toronto, Ontario M5S 1A1, CanadaDepartment of Mathematics and Statistics, University of Guelph, Guelph, Ontario N1G 2W1, Canada,CNLS, Los Alamos National Laboratory, Los Alamos, New Mexico 87545.

出版信息

Chaos. 1993 Jan;3(1):7-13. doi: 10.1063/1.165967.

DOI:10.1063/1.165967

PMID:12780009

Abstract

Reactive lattice gas automata simulations show that Turing structure can form on a mesoscopic scale and are stable to molecular fluctuations in this domain. Calculations on the Sel'kov model suggest that Turing instabilities can give rise to global spatial symmetry breaking in ATP concentration within the cell cytoplasm with a mesoscopic Turing scale well within typical cell dimensions. This leads to a new mechanism for the global breaking of energy distribution in the cell. It also leads to reappraisal of the importance of the Turing effect on extended biochemical spatial structures and energy transport available to cell morphogenesis.

摘要

反应晶格气体自动机模拟表明，图灵结构可以在介观尺度上形成，并且在该领域对分子涨落具有稳定性。对塞尔科夫模型的计算表明，图灵不稳定性可以导致细胞质中ATP浓度的全局空间对称性破缺，其介观图灵尺度完全在典型细胞尺寸范围内。这导致了细胞内能量分布全局破缺的一种新机制。它还导致重新评估图灵效应在扩展生化空间结构和细胞形态发生可用能量传输方面的重要性。