[Effect of cardiac glycosides on isoprenaline-induced heart changes].

The authors carried out studies on rats to examine the influence of preliminary treatment with strophanitine G on myocardial necrosis, induced by isoprenaline, evaluated by the changes in the number of leucocytes, erythrocyte sedimentation rate and the activity of SGPT in the peripheral blood, by the changes in the cardiac frequency and ECG as well as by the histologic and histochemical changes in the myocardium. It was established that strophanitine G potentiated the cardiotoxic action of isoprenaline, evaluated by hamatological, biochemical, electrocardiographic and histologic changes. The authors discuss the possible mechanisms of this interaction between digitalis glucoside and isoprenaline.