Bielecki K, Kolodziejczak M
Department Surgery, Medical Centre for Postgraduate Education, Orlowski Hospital, 231 Czerniakowska str. 00-416, Warsaw, Poland.
Colorectal Dis. 2003 May;5(3):256-7. doi: 10.1046/j.1463-1318.2003.00440.x.
The aim of this study was to compare prospectively diltiazem with GTN ointment in the treatment of anal fissure.
Of 43 outpatients with chronic anal fissure, 22 patients were randomized to topical diltiazem (2%) ointment and 21 patients to glyceryltrinitrate (GTN) (0.5%) ointment twice daily for 8 weeks. During the course of treatment each patient was seen three times. Side-effects and healing were recorded.
Healing occurred in 19 of 22 patients treated with diltiazem and 18 of 21 patients were cured with GTN (P = 0.95). Those who were treated with nitroglycerin ointment developed headache and dizziness developed after GTN in 33.3% of cases while no patient had any side-effects after diltiazem.
Diltiazem and glyceryltrinitrate (GTN) were equally effective in healing anal fissure but the former resulted in fewer side-effects.
本研究旨在前瞻性比较地尔硫䓬与硝酸甘油软膏治疗肛裂的效果。
43例慢性肛裂门诊患者，22例随机接受局部使用2%地尔硫䓬软膏，21例接受0.5%硝酸甘油软膏治疗，均每日两次，持续8周。治疗过程中，每位患者接受三次检查。记录副作用及愈合情况。
地尔硫䓬治疗的22例患者中19例愈合，硝酸甘油治疗的21例患者中18例治愈（P = 0.95）。硝酸甘油软膏治疗的患者中33.3%出现头痛和头晕，而地尔硫䓬治疗后无患者出现任何副作用。
地尔硫䓬和硝酸甘油治疗肛裂的效果相同，但前者副作用更少。
