Maki Robert G
Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 223, New York, NY 10021-6007, USA.
Curr Oncol Rep. 2003 Jul;5(4):282-7. doi: 10.1007/s11912-003-0067-x.
Recent advances in basic medical sciences have led to a deeper understanding of the molecular characteristics of soft-tissue sarcomas. Likewise, novel technologies have led to a better appreciation of the relationship between an antigenic stimulus and the subsequent immune response against the antigen. In the past few years, the intersection of the understanding of the immune system and the knowledge of sarcoma biology has become apparent. As seen with other forms of cancer, there is a detectable autologous immune response against sarcomas. It is the hope of many investigators that the hints of a tumor-specific immune response will be enough to generate a signal that can be amplified and directed against the host sarcoma. The data regarding the initial evidence of immune responses against sarcomas are reviewed in the context of current or potential clinical studies.
基础医学科学的最新进展使人们对软组织肉瘤的分子特征有了更深入的了解。同样，新技术也使人们更好地认识了抗原刺激与随后针对该抗原的免疫反应之间的关系。在过去几年中，对免疫系统的理解与肉瘤生物学知识的交叉点已变得明显。与其他癌症形式一样，存在针对肉瘤的可检测到的自体免疫反应。许多研究人员希望，肿瘤特异性免疫反应的迹象将足以产生一个可以被放大并针对宿主肉瘤的信号。本文在当前或潜在临床研究的背景下，对针对肉瘤免疫反应的初步证据的数据进行了综述。
