Karger Randy A, Jeng Samuel M, Johnson Douglas H, Hodge David O, Good Margaret S
Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
J Glaucoma. 2003 Jun;12(3):193-7. doi: 10.1097/00061198-200306000-00002.
To determine the incidence of newly diagnosed pseudoexfoliation syndrome and pseudoexfoliation glaucoma in residents of Olmsted County, Minnesota from 1976 to 1991.
The database of the Rochester Epidemiology Project was used to identify all patients residing in Olmsted County who were newly diagnosed with pseudoexfoliation syndrome from 1976 to 1991. The criterion used to diagnose pseudoexfoliation syndrome was the presence of pseudoexfoliation material on 1 or more anterior segment structures. Criteria used to diagnose pseudoexfoliation glaucoma were diagnosis of pseudoexfoliation syndrome with evidence of glaucomatous changes or ocular hypertension receiving therapy. The overall age and sex-adjusted annual incidences of pseudoexfoliation syndrome and pseudoexfoliation glaucoma, adjusted to the 1990 US white population, were determined with differences across age and sex using Poisson regression.
Pseudoexfoliation syndrome was diagnosed in 290 patients (mean age, 73 +/- 10 years). Two hundred twenty-one (76%) were female. The overall age and sex-adjusted annual incidence of pseudoexfoliation syndrome was 25.9 per 100,000. The age-adjusted incidence was higher in females than in males (32.7 vs 16.9 per 100,000; P<0.001). Pseudoexfoliation syndrome diagnoses increased with age, from 2.8 per 100,000 in persons 40 to 49 years to 205.7 per 100,000 in persons > or =80 years (P<0.001). Thirty-five patients were excluded from pseudoexfoliation glaucoma diagnosis. Of the remaining 255 patients, 113 (44%) were diagnosed with pseudoexfoliation glaucoma during the study period (mean age, 76 +/- 10 years), 84 (74%) of whom were female. The overall age- and sex-adjusted annual incidence of pseudoexfoliation glaucoma was 9.9 per 100,000. The age-adjusted incidence was higher in females than in males (11.7 vs 7.2 per 100,000; P < 0.001). Pseudoexfoliation glaucoma was increasingly diagnosed with age, rising from 0.6 per 100,000 in persons 40 to 49 years to 114.3 per 100,000 in persons > or =80 years, (P<0.001).
In a defined population, the estimated overall age- and sex-adjusted annual incidence of pseudoexfoliation syndrome was 25.9 per 100,000 population, while the estimated overall age- and sex-adjusted annual incidence of pseudoexfoliation glaucoma was 9.9 per 100,000 population. The incidence of both diseases was higher in females and increased with advancing age.
确定1976年至1991年明尼苏达州奥尔姆斯特德县居民中新诊断的假性剥脱综合征和假性剥脱性青光眼的发病率。
利用罗切斯特流行病学项目的数据库，识别出1976年至1991年期间居住在奥尔姆斯特德县且新诊断为假性剥脱综合征的所有患者。诊断假性剥脱综合征的标准是在1个或更多眼前节结构上存在假性剥脱物质。诊断假性剥脱性青光眼的标准是诊断为假性剥脱综合征且有青光眼性改变的证据或接受治疗的高眼压。采用泊松回归分析年龄和性别差异，确定经年龄和性别调整后的假性剥脱综合征和假性剥脱性青光眼的总体年发病率，并根据1990年美国白人人口进行调整。
290例患者被诊断为假性剥脱综合征（平均年龄73±10岁）。其中221例（76%）为女性。经年龄和性别调整后的假性剥脱综合征总体年发病率为每10万人25.9例。女性的年龄调整发病率高于男性（每10万人32.7例对16.9例；P<0.001）。假性剥脱综合征的诊断随年龄增加而增加，从40至49岁人群中的每10万人2.8例增至80岁及以上人群中的每10万人205.7例（P<0.001）。35例患者被排除在假性剥脱性青光眼诊断之外。在其余255例患者中，113例（44%）在研究期间被诊断为假性剥脱性青光眼（平均年龄76±10岁），其中84例（74%）为女性。经年龄和性别调整后的假性剥脱性青光眼总体年发病率为每10万人9.9例。女性的年龄调整发病率高于男性（每10万人11.7例对7.2例；P<0.001）。假性剥脱性青光眼的诊断也随年龄增加而增加，从40至49岁人群中的每10万人0.6例增至80岁及以上人群中的每10万人114.3例（P<0.001）。
在特定人群中，经年龄和性别调整后的假性剥脱综合征估计总体年发病率为每10万人25.9例，而经年龄和性别调整后的假性剥脱性青光眼估计总体年发病率为每10万人9.9例。这两种疾病的发病率在女性中更高，且随年龄增长而增加。
