VST Glaucoma Centre, Dr. Kallam Anji Reddy Campus, L V Prasad Eye Institute, Banjara Hills, Hyderabad, India.
Allen Foster Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye care, L V Prasad Eye Institute, Kismatpur Road, Himayathsagar, Hyderabad, Telangana, India.
Eye (Lond). 2023 Jun;37(8):1704-1710. doi: 10.1038/s41433-022-02226-9. Epub 2022 Sep 9.
To report the 15-year incidence rate of pseudo-exfoliation (PXF), PXF glaucoma and regional variation among rural participants in the Andhra Pradesh Eye Disease Study (APEDS) III.
This population-based longitudinal study was carried out at three rural study sites. Individuals of all ages who participated at baseline with a mean 15-year follow-up visit were included. Detailed Comprehensive ophthalmic examination was performed on all participants. The main outcome measure was development of PXF during the follow-up period in participants who were phakic in one or both eyes without PXF at baseline.
Among 5395 participants, 5108 (94.6%) met the inclusion criteria. There were 93 (1.82%; 95% confidence interval (CI), 1.47-2.22) cases of incident PXF. Their median baseline age (1st, 3rd quartiles) was 51 (44, 59) years and the male: female ratio was 1.3:1. There was no case of incident PXF in participants aged <30 years at baseline. The incidence rate per 100 person years (95% CI) among all ages and those aged ≥30 years at baseline was 1.73 (1.64-1.82) and 3.73 (3.53-3.93), respectively. PXF material was located on iris as well as anterior surface of lens and it was often bilateral. Participants living in two study sites and increasing age were associated with the incidence of PXF. The 15-year incidence of PXF glaucoma (95% CI) in participants ≥30 years of age at baseline was 0.33% (0.14-0.66).
There is significant regional variation in incidence of PXF in south India which warrants further investigation.
报告安得拉邦眼病研究 III（APEDS III）中农村参与者的 15 年假剥脱（PXF）、PXF 青光眼和区域差异发生率。
这是一项基于人群的纵向研究，在三个农村研究点进行。纳入了在基线时参加且在平均 15 年随访时年龄均在 15 岁以上的所有年龄段的个体。对所有参与者进行详细的全面眼科检查。主要结局指标是在基线时无 PXF 的一只或两只眼为白内障的参与者在随访期间发生 PXF。
在 5395 名参与者中，有 5108 名（94.6%）符合纳入标准。有 93 例（1.82%；95%置信区间[CI]，1.47-2.22）新发性 PXF 病例。他们的中位基线年龄（1 分位数、3 分位数）为 51 岁（44、59），男女比例为 1.3:1。基线年龄<30 岁的参与者中没有新发性 PXF 病例。所有年龄组和基线年龄≥30 岁的参与者每 100 人年（95%CI）的发生率分别为 1.73（1.64-1.82）和 3.73（3.53-3.93）。PXF 物质位于虹膜和晶状体前表面，且通常为双侧。居住在两个研究点的参与者和年龄增长与 PXF 的发生有关。基线年龄≥30 岁的参与者中，15 年 PXF 青光眼（95%CI）的发生率为 0.33%（0.14-0.66）。
印度南部 PXF 的发病率存在显著的地域差异，这需要进一步调查。
