Rutledge Bridget, Huyette David, Day Delbert, Anglen Jeff
Department of Orthopaedic Surgery, University of Missouri-Columbia Hospital & Clinics, Columbia, MO 65212, USA.
Clin Orthop Relat Res. 2003 Jun(411):280-7. doi: 10.1097/01.blo.0000065836.93465.ed.
The purpose of the current study was to show the efficacy and safety of an absorbable polymer (polycaprolactone) as an antibiotic delivery vehicle for treatment of osteomyelitis. An intramedullary osteomyelitis was induced in the femur of adult rabbits by Staphylococcus aureus inoculation after use of a sclerosing agent, and then treatment was done with intramedullary irrigation and implantation of a rod made of polycaprolactone, polycaprolactone plus 6% tobramycin, or polymethylmethacrylate plus 6% tobramycin. A control group received irrigation only. At defined intervals, the animals were euthanized and culture of the inoculated site was done. In addition, histologic sections of body tissues were made to look for signs of systemic toxicity of the implant. After 4 weeks of treatment, a statistically significant difference was found between the animals that were treated with irrigation alone and the animals that were treated with antibiotic-laden rods of polycaprolactone or polymethylmethacrylate. There was no difference between the antibiotic rod types. No histologic evidence of toxicity was found. Bioabsorbable rods of polycaprolactone are a safe and effective means of antibiotic delivery for treatment of osteomyelitis.
本研究的目的是展示一种可吸收聚合物（聚己内酯）作为抗生素递送载体治疗骨髓炎的有效性和安全性。在成年兔股骨中使用硬化剂后接种金黄色葡萄球菌诱导髓内骨髓炎，然后通过髓内冲洗并植入由聚己内酯、聚己内酯加6%妥布霉素或聚甲基丙烯酸甲酯加6%妥布霉素制成的棒进行治疗。对照组仅接受冲洗。在规定的时间间隔，对动物实施安乐死并对接种部位进行培养。此外，制作身体组织的组织学切片以寻找植入物全身毒性的迹象。治疗4周后，发现仅接受冲洗治疗的动物与接受聚己内酯或聚甲基丙烯酸甲酯载抗生素棒治疗的动物之间存在统计学上的显著差异。抗生素棒类型之间没有差异。未发现毒性的组织学证据。聚己内酯生物可吸收棒是治疗骨髓炎的一种安全有效的抗生素递送手段。
