沙利度胺诱发家兔背根神经节的超微结构变化
Ultrastructural changes in the dorsal root ganglia evoked by thalidomide in rabbits.
作者信息
Stokes P A, Lykke W J, McBride W G
出版信息
Experientia. 1976 May 15;32(5):597-9. doi: 10.1007/BF01990184.
PMID:1278308
Abstract
Administration of the teratogenic drug thalidomide to pregnant does produces ultrastructural changes in foetal ganglion cells, Schwann cells and axons in the posterior root ganglia corresponding to forelimb segments deformed by the orug. Ultrastructural changes in ganglia appear on the 13th day of gestation, i.e., preceding the appearance of limb malformation.
摘要
给怀孕的母鼠施用致畸药物沙利度胺，会使胎儿神经节细胞、施万细胞和后根神经节中的轴突发生超微结构变化，这些变化与药物导致的前肢节段畸形相对应。神经节的超微结构变化在妊娠第13天出现，即在肢体畸形出现之前。
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