Blakemore W F
J Neurocytol. 1975 Dec;4(6):745-57. doi: 10.1007/BF01181634.
Focal areas of primary demyelination were produced in the spinal cords of rats by means of local injections of 6-aminonicotinamide. Both astrocytes and oligodendrocytes underwent degeneration in the demyelinated area. Nearly all the demyelinated axons were remyelinated by Schwann cells; only a very small number of axons located adjacent to normally myelinated axons were remyelinated by oligodendrocytes. The glial limiting membrane was reconstituted around the ecge of the area remyelinated by Schwann cells. This experiment offers further evidence for an important role of astrocytes in controlling Schwann cell invasion of the central nervous system, and in addition suggests that astrocytes are also needed for oligodendrocyte remyelination to take place.
通过局部注射6-氨基烟酰胺在大鼠脊髓中产生原发性脱髓鞘的病灶区域。在脱髓鞘区域，星形胶质细胞和少突胶质细胞均发生变性。几乎所有脱髓鞘轴突都由施万细胞重新髓鞘化；只有极少数位于正常髓鞘化轴突附近的轴突由少突胶质细胞重新髓鞘化。在由施万细胞重新髓鞘化区域的边缘周围重新形成了胶质界膜。该实验进一步证明了星形胶质细胞在控制施万细胞侵入中枢神经系统方面的重要作用，此外还表明少突胶质细胞进行重新髓鞘化也需要星形胶质细胞。
