Doggrell Sheila A
School of Biomedical Sciences, The University of Queensland, QLD 4072, Australia.
Expert Opin Investig Drugs. 2003 Jun;12(6):1035-8. doi: 10.1517/13543784.12.6.1035.
Melanin-concentrating hormone (MCH) is orexigenic (stimulates food intake). Two receptors for MCH have been identified in humans, MCH1-R and MCH2-R. SNAP-7941 is a small molecule MCH1-R antagonist. SNAP-7941 inhibits MCH-induced food intake in rats. SNAP-7941 alone reduced weight gain in young growing rats and in mature rats fed a high-fat diet. Preliminary testing with SNAP7941 in animal models of depression and anxiety shows it has antidepressant and anxiolytic effects. SNAP7941 should undergo further development as an anorectic, antidepressant and anxiolytic.
促黑素细胞激素（MCH）具有促食欲作用（刺激食物摄入）。已在人类中鉴定出两种MCH受体，即MCH1-R和MCH2-R。SNAP-7941是一种小分子MCH1-R拮抗剂。SNAP-7941可抑制大鼠中MCH诱导的食物摄入。单独使用SNAP-7941可减少幼年生长大鼠和高脂饮食喂养的成年大鼠的体重增加。在抑郁症和焦虑症动物模型中对SNAP7941进行的初步测试表明，它具有抗抑郁和抗焦虑作用。SNAP7941应作为一种食欲抑制剂、抗抑郁药和抗焦虑药进行进一步开发。
