噻嗪类利尿剂与去氨加压素联合成功治疗部分性肾性尿崩症。
Successful treatment of partial nephrogenic diabetes insipidus with thiazide and desmopressin.
作者信息
Mizuno Haruo, Fujimoto Shinji, Sugiyama Yukari, Kobayashi Masanori, Ohro Yoichiro, Uchida Shinichi, Sasaki Sei, Togari Hajime
机构信息
Department of Pediatrics, Neonatology and Congenital Disorders, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan.
出版信息
Horm Res. 2003;59(6):297-300. doi: 10.1159/000070629.
OBJECTIVE
To clarify whether combination treatment with desmopressin (DDAVP) and thiazide was clinically effective in a patient with congenital nephrogenic diabetes insipidus (CNDI), we evaluated the treatment in a 7-year-old boy with CNDI who had demonstrated a partial response to DDAVP.
METHOD
Both volume of urine and the presence of nocturia were determined during treatment.
RESULT
Neither the usual therapy of a low-salt diet and a thiazide nor intranasal therapy with a large dose of DDAVP was effective. However, combination treatment resulted in a decrease in urinary volume and the disappearance of nocturia.
CONCLUSION
DDAVP coupled with thiazide may be useful for CNDI in patients who have shown a partial response to DDAVP.
目的
为了阐明去氨加压素（DDAVP）与噻嗪类药物联合治疗对先天性肾性尿崩症（CNDI）患者是否具有临床疗效，我们对一名7岁患CNDI且对DDAVP有部分反应的男孩的治疗情况进行了评估。
方法
在治疗期间测定尿量和夜尿情况。
结果
低盐饮食加噻嗪类药物的常规治疗以及大剂量DDAVP鼻内给药治疗均无效。然而，联合治疗使尿量减少且夜尿消失。
结论
对于对DDAVP有部分反应的CNDI患者，DDAVP联合噻嗪类药物可能有效。
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