Department of Endocrinology and Diabetes, NTT Medical Center Tokyo, Japan.
Department of Psychosomatic Medicine, NTT Medical Center Tokyo, Japan.
Intern Med. 2024 May 15;63(10):1399-1404. doi: 10.2169/internalmedicine.2437-23. Epub 2023 Sep 29.
Nephrogenic diabetes insipidus (NDI) is characterized by excessive urination and an inability to concentrate urine. Lithium is the most common cause of acquired NDI. Treatment typically involves thiazide diuretics and nonsteroidal anti-inflammatory drugs (NSAIDs). However, the efficacy of desmopressin in NDI remains unclear. We herein report a case of lithium-induced NDI in a 71-year-old woman with lithium-induced NDI. Thiazide diuretics and NSAIDs reduced the urine output by approximately 40% compared to pretreatment, while the addition of desmopressin reduced it by approximately 70%. This case suggests that desmopressin can be a viable treatment option for lithium-induced NDI.
肾源性尿崩症（NDI）的特征是排尿过多和无法浓缩尿液。锂是获得性 NDI 的最常见原因。治疗通常包括噻嗪类利尿剂和非甾体抗炎药（NSAIDs）。然而，去氨加压素在 NDI 中的疗效尚不清楚。本文报告了一例 71 岁女性锂诱导的 NDI 病例。与治疗前相比，噻嗪类利尿剂和 NSAIDs 将尿量减少了约 40%，而添加去氨加压素则将尿量减少了约 70%。该病例提示去氨加压素可能是锂诱导的 NDI 的一种可行治疗选择。
