Gayda M, Merzouk A, Choquet D, Doutrellot P L, Ahmaidi S
Laboratoire de recherche EA 3300 APS et Conduites Motrices: Adaptations et Réadaptations, Faculté des Sciences du Sport, Université de Picardie Jules Verne, 80025 Amiens Cedex 1, France.
Int J Sports Med. 2003 May;24(4):258-63. doi: 10.1055/s-2003-39507.
The aim of this study was to determine if the diminished aerobic capacity of coronary artery disease male (CAD) patients is accompanied by an impaired skeletal muscle function compared to healthy control subjects. Thirteen CAD patients and 9 healthy subjects performed both a maximal laboratory exercise testing and an assessment of the peripheral skeletal muscle function on an isokinetic apparatus. The cardiorespiratory and mechanical parameters were measured at ventilatory threshold and at maximal effort during a maximal exercise testing. The peripheral skeletal muscle function of the quadriceps was assessed from the maximal voluntary isometric force (MVIF) and from the static endurance time (SET) at an intensity of 50 % of the MVIF. The CAD patients showed a diminished aerobic capacity compared to healthy control subjects at maximal effort (maximal VO(2) uptake: p < 0.0001, maximal ventilation: p < 0.01; maximal heart rate: p < 0.0001, maximal power: p < 0.001) but also at VT (VO(2) uptake VT: p < 0.0001, Power VT: p < 0.001). No difference was found on the MVIF (p < 0.90) between the CAD patients and the control subjects whereas the SET was lower in the CAD patients (p < 0.01). The CAD patients had a lower aerobic capacity and an impaired skeletal muscle endurance compared to healthy subjects.
本研究的目的是确定与健康对照受试者相比，冠状动脉疾病男性（CAD）患者有氧能力下降是否伴有骨骼肌功能受损。13名CAD患者和9名健康受试者进行了最大实验室运动测试以及在等速装置上对外周骨骼肌功能的评估。在最大运动测试期间，在通气阈值和最大努力时测量心肺和力学参数。股四头肌的外周骨骼肌功能通过最大自主等长肌力（MVIF）和MVIF强度50%时的静态耐力时间（SET）进行评估。与健康对照受试者相比，CAD患者在最大努力时（最大摄氧量：p<0.0001，最大通气量：p<0.01；最大心率：p<0.0001，最大功率：p<0.001）以及在通气阈值时（摄氧量VT：p<0.0001，功率VT：p<0.001）有氧能力均下降。CAD患者与对照受试者之间的MVIF无差异（p<0.90），而CAD患者的SET较低（p<0.01）。与健康受试者相比，CAD患者有氧能力较低且骨骼肌耐力受损。
