Startsev V Iu, Karelin M I
Central Research Institute of Roentgeno-Radiology, St. Petersburg.
Vopr Onkol. 2003;49(2):235-8.
Organ preservation has been investigated inmuscle-invasivebladder cancer over the past years as an alternative to standard radical cystectomy. However, the morbidity of radical cystectomy and early reports of good results of radical transuretheral resection of bladder tumors (TURBT) have stimulated interest in combined treatment for muscle-invasive bladder cancer. Organ preservation requires a trimodal schedule, including transuretheral surgery, mega voltage radical external beam radiotherapy (EBRT) and adjuvant chemotherapy (ACT). Our results point to the effectiveness of combined therapy of urinary bladder in old patients with invasive, advanced cancer (stage T2). These results demonstrate the effectness of intra-arterial ACT when used in combination with EBRT.
在过去几年中,人们对肌层浸润性膀胱癌的器官保留进行了研究,作为标准根治性膀胱切除术的替代方法。然而,根治性膀胱切除术的发病率以及早期关于根治性经尿道膀胱肿瘤切除术(TURBT)良好结果的报道,激发了人们对肌层浸润性膀胱癌联合治疗的兴趣。器官保留需要一个三联模式的方案,包括经尿道手术、兆伏级根治性外照射放疗(EBRT)和辅助化疗(ACT)。我们的结果表明,联合治疗对老年浸润性晚期癌症(T2期)患者的膀胱有效。这些结果证明了动脉内ACT与EBRT联合使用时的有效性。