Colvett K T, Althausen A F, Bassil B, Heney N M, McGovern F V, Young H H, Kaufman D S, Zietman A L, Shipley W U
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
J Surg Oncol. 1996 Nov;63(3):201-8. doi: 10.1002/(SICI)1096-9098(199611)63:3<201::AID-JSO13>3.0.CO;2-7.
Combined-modality therapy for organ preservation represents an appropriate alternative to radical surgery in the management of several malignant diseases. The standard therapy for muscle-invasive bladder cancer in the United States has been radical cystectomy. Although the sequelae of radical surgery have been ameliorated somewhat by techniques for the construction of orthotopic bladders, the ideal therapy should both cure the patient of cancer and maintain a functioning natural bladder. Years of experience in Europe and Canada with bladder preservation using radiation therapy are documented. Advances in transurethral surgery technique and in the combination of radiation and chemotherapy have led to safe and effective regimens for patients with bladder cancer. Several recent trials with combined-modality therapy have established this treatment as a viable alternative to radical cystectomy in selected patients.
在多种恶性疾病的治疗中，器官保留的联合治疗是根治性手术的一种合适替代方案。在美国，肌层浸润性膀胱癌的标准治疗方法一直是根治性膀胱切除术。尽管通过原位膀胱构建技术，根治性手术的后遗症在一定程度上有所改善，但理想的治疗方法应既能治愈患者的癌症，又能维持天然膀胱的功能。欧洲和加拿大在使用放射治疗保留膀胱方面已有多年经验记录。经尿道手术技术以及放疗与化疗联合应用的进展，已为膀胱癌患者带来了安全有效的治疗方案。最近的几项联合治疗试验已证实，对于特定患者，这种治疗方法是根治性膀胱切除术的可行替代方案。
