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[肾脏β-肾上腺素能受体在调节其血液供应和尿液生成中的作用]

[The role of renal beta-adrenoreceptors in regulating its blood supply and urine formation].

作者信息

Gorpinchenko E I

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1976 May;62(5):776-82.

PMID:1278558
Abstract

The dog kidney blood flow and filtrative and reabsorptive functions were studied with the aid of electromagnetic flowmeter and endogenic creatinine. Beta-adrenostimulation with izadrine caused dilatation of the kidney vessels. Beta-adrenoblockade led to the opposite though insignificant effect. Beta-adrenostimulation in intact animals entailed systemic hypotension, activation of the kidney blood flow and reabsorption, decrease of filtration and diuresis. Following stabilization of arterial pressure or central inhibition of vasopressin, the beta-adrenostimulation led to the decrease in reabsorption. The data obtained seem to indicate that the direct effect of beta-adrenostimulation of the kidney channels is manifested by the inhibition of reabsorption.

摘要

借助电磁流量计和内源性肌酐,对犬肾血流量以及滤过和重吸收功能进行了研究。用异丙肾上腺素进行β-肾上腺素能刺激可导致肾血管扩张。β-肾上腺素能阻断则产生相反但不显著的效应。在未受损动物中进行β-肾上腺素能刺激会引起全身性低血压、肾血流量和重吸收的激活、滤过和利尿的减少。在动脉压稳定或对血管加压素进行中枢抑制后,β-肾上腺素能刺激会导致重吸收减少。所获得的数据似乎表明,对肾通道的β-肾上腺素能刺激的直接作用表现为对重吸收的抑制。

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