新型铑催化的1,6-烯炔分子内卤素迁移的环异构化反应

Novel rhodium-catalyzed cycloisomerization of 1,6-enynes with an intramolecular halogen shift.

作者信息

Tong Xiaofeng, Zhang Zhaoguo, Zhang Xumu

机构信息

State Key Laboratory of Organometallics, Shanghai Institute of Organic Chemistry, Shanghai, 200032, P. R. China.

出版信息

J Am Chem Soc. 2003 May 28;125(21):6370-1. doi: 10.1021/ja034096j.

DOI:10.1021/ja034096j

PMID:12785768

Abstract

A new Rh-catalyzed 1,6-enyne cycloisomerization process with a pi-allyl rhodium species as the key intermediate is investigated. A halogen shift happened in this novel process. The synthesis of stereodefined alpha-halomethylene gamma-butyrolactones has been achieved using the readily accessible Rh catalysts.

摘要

研究了一种以π-烯丙基铑物种作为关键中间体的新型铑催化的1,6-烯炔环异构化过程。在这一新型过程中发生了卤素迁移。使用易于获得的铑催化剂实现了立体定向的α-卤代亚甲基γ-丁内酯的合成。