Cottone M, Orlando A, Viscido A, Calabrese E, Cammà C, Casà A
Clinica Medica R Università di Palermo, Cattedra di Gastroenterologia Roma, CNR Palermo, Italy.
Aliment Pharmacol Ther. 2003 Jun;17 Suppl 2:38-42. doi: 10.1046/j.1365-2036.17.s2.12.x.
After first resection in Crohn's disease at 1 year 60-80% of patients have endoscopic recurrence, 10-20% have clinical relapse, and 5% have surgical recurrence.1, 2 This review focuses on the actual evidence on the prevention of recurrence and relapse dealing with risk factors and with drugs. Smoking is the only risk factor for Crohn's disease, that has been shown to be related to both endoscopic and surgical recurrence and relapse. Among the different drugs evaluated, some (Mesalamine and Metronidazole) have been shown to be effective, whereas others (immunosuppressive) need to be evaluated in further, new trials.
在克罗恩病首次切除术后1年，60 - 80%的患者出现内镜复发，10 - 20%出现临床复发，5%出现手术复发。1,2本综述聚焦于预防复发和再发的实际证据，涉及风险因素和药物。吸烟是克罗恩病唯一已被证明与内镜及手术复发和再发均相关的风险因素。在评估的不同药物中，一些（美沙拉嗪和甲硝唑）已被证明有效，而其他药物（免疫抑制剂）则需要在进一步的新试验中进行评估。
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