Fornaro Rosario, Frascio Marco, Stabilini Cesare, Sticchi Camilla, Barberis Andrea, Denegri Andrea, Ricci Barbara, Azzinnaro Antonio, Lazzara Fabrizio, Gianetta Ezio
Patologia Chirurgica a Indirizzo Gastroenterologico, Dipartimento di Discipline Chirurgiche e Metodologie Integrate, Università degli Studi di Genova.
Chir Ital. 2008 Nov-Dec;60(6):761-81.
Crohn's disease is associated with high rates of postoperative recurrence. By 10 years postoperatively a high percentage of patients suffer clinical relapses (as many as 75% and above) and many of these (up to 45%) require re-intervention. The aim of the study was to identify, among the various potentially predictive factors, those which today can be considered real risk factors for postoperative recurrence. A review of the literature of the last two decades was carried out. Factors related to the patient, disease, type of surgery and pharmacological treatment were analysed. The relapse rate we recorded was 41.17% (28 of 62 patients operated on in the last 20 years and included in an average 6-year follow-up (range: 1-19 years). Significant predictive factors, in adition to duration of the follow-up and smoking, are also the location of the disease in the colon, extent more than 100 cm and the absence of postoperative pharmacological prophylaxis. The high incidence of postoperative recurrence in Crohn's disease mandates a strict follow-up (clinical, laboratory and instrumental monitoring). Identifying patients at increased risk would enable physicians to implement a rational pharmacological prophylaxis.
