小肠通透性。1. 缺血及接触乙酰水杨酸的影响。
Small intestinal permeability. 1. Effects of ischaemia and exposure to acetyl salicylate.
作者信息
Kingham J G, Whorwell P J, Loehry C A
出版信息
Gut. 1976 May;17(5):354-61. doi: 10.1136/gut.17.5.354.
Abstract
Permeability of the small intestinal mucosa was estimated using a perfusion technique after either a period of ischaemia or exposure to acetyl salicylate. It was shown that these procedures increased the passive permeability of the mucosa to macromolecules while maintaining normal mucosal selectivity. Histologically, there was derangment of the epithelial cell layer of the villous tips without damage to the epithelial basement membrane or subepithelial structures. It is concluded that the epithelial cell layer is purely limiting with no selective function and that the role of selectivity must be ascribed to either or both of the other mucosal barriers, the capillary and the epithelial basement membrane.
摘要
在经历一段缺血期或暴露于乙酰水杨酸后，采用灌注技术评估小肠黏膜的通透性。结果显示，这些操作增加了黏膜对大分子的被动通透性，同时保持了正常的黏膜选择性。组织学上，绒毛尖端的上皮细胞层紊乱，但上皮基底膜和上皮下结构未受损。得出的结论是，上皮细胞层仅起限制作用，没有选择性功能，选择性的作用必须归因于其他黏膜屏障中的一个或两个，即毛细血管和上皮基底膜。
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