Ichimura Koichi, Kagami Yoshitoyo, Suzuki Ritsuro, Kojima Masaru, Yoshino Tadashi, Ohshima Koichi, Koike Koichi, Kondo Eisei, Taji Hirofumi, Ogura Michinori, Morishima Yasuo, Akagi Tadaatsu, Takahashi Toshitada, Nakamura Shigeo
Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.
Pathol Int. 2003 Jun;53(6):333-44. doi: 10.1046/j.1440-1827.2003.01479.x.
The World Health Organization (WHO) classification of malignant lymphoma presented a list of disease entities well defined by clinical, immunological and genetic features. Therefore, the current diagnosis of peripheral T/NK-cell lymphomas (PTNKLs) essentially requires the inclusion of anatomical sites of disease and phenotypical features. We analyzed 408 Japanese cases of PTNKLs in order to clarify the relationship between anatomical sites of disease and phenotypical features and to translate the functional subsets of T and NK cells into their diagnoses for further understanding lymphomatic biology. The T/NK-cell lymphoma entities were allocated into three categories: (i) cytotoxic memory T-cell and/or NK-cell lymphoma (n = 151) consisting of extranodal NK/T-cell tumors other than mycosis fungoides (MF); (ii) non-cytotoxic memory T-cell lymphoma (n = 142) consisting of nodal and cutaneous tumors such as angioimmunoblastic T-cell lymphoma, adult T-cell lymphoma/leukemia and MF; and (iii) anaplastic lymphoma kinase positive anaplastic large cell lymphoma (n = 110) that has unique features and might be regarded as cytotoxic 'naive' T-cell lymphoma. Overall, these three categories were significantly correlated with age of onset, anatomical sites, the level of expression of cytotoxic molecules and CD45RO, and association with Epstein-Barr virus. This concept might provide a new insight enabling further understanding of the interrelationships among WHO T/NK-cell disease entities.
世界卫生组织（WHO）的恶性淋巴瘤分类列出了一系列由临床、免疫和遗传特征明确界定的疾病实体。因此，目前外周T/NK细胞淋巴瘤（PTNKL）的诊断基本上需要纳入疾病的解剖部位和表型特征。我们分析了408例日本PTNKL病例，以阐明疾病解剖部位与表型特征之间的关系，并将T细胞和NK细胞的功能亚群转化为诊断，以便进一步了解淋巴瘤生物学。T/NK细胞淋巴瘤实体分为三类：（i）细胞毒性记忆T细胞和/或NK细胞淋巴瘤（n = 151），包括蕈样霉菌病（MF）以外的结外NK/T细胞肿瘤；（ii）非细胞毒性记忆T细胞淋巴瘤（n = 142），包括淋巴结和皮肤肿瘤，如血管免疫母细胞性T细胞淋巴瘤、成人T细胞淋巴瘤/白血病和MF；（iii）间变性淋巴瘤激酶阳性间变性大细胞淋巴瘤（n = 110），其具有独特特征，可能被视为细胞毒性“幼稚”T细胞淋巴瘤。总体而言，这三类与发病年龄、解剖部位、细胞毒性分子和CD45RO的表达水平以及与爱泼斯坦-巴尔病毒的关联显著相关。这一概念可能提供新的见解，有助于进一步理解WHO T/NK细胞疾病实体之间的相互关系。
