Veillette André, Latour Sylvain
Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montréal, Québec, Canada.
Curr Opin Immunol. 2003 Jun;15(3):277-85. doi: 10.1016/s0952-7915(03)00041-4.
The 'signalling lymphocyte activation molecule' (SLAM) family is a newly appreciated group of immune-cell specific receptors that has the ability to regulate the function of several immune cell types. Recent studies show that the SLAM-related receptors mediate intracellular protein tyrosine phosphorylation signals. This property is dependent on the aptitude of SLAM-family receptors to bind with high affinity to SAP and/or EAT-2, two small adaptor molecules composed almost exclusively of a Src homology 2 domain. SAP is mutated in X-linked lymphoproliferative disease, a human immune dysfunction characterised by an inappropriate response to Epstein-Barr virus infection, thereby suggesting that the SLAM-related receptors may be critical for a normal immune response. The existence of the SLAM family broadens the spectrum of receptors known to be involved in immunomodulation.
“信号淋巴细胞激活分子”（SLAM）家族是一组新发现的免疫细胞特异性受体，能够调节多种免疫细胞类型的功能。最近的研究表明，与SLAM相关的受体介导细胞内蛋白酪氨酸磷酸化信号。这一特性取决于SLAM家族受体与SAP和/或EAT-2高亲和力结合的能力，这两种小衔接分子几乎完全由Src同源2结构域组成。SAP在X连锁淋巴增殖性疾病中发生突变，这是一种人类免疫功能障碍，其特征是对爱泼斯坦-巴尔病毒感染反应异常，从而表明与SLAM相关的受体可能对正常免疫反应至关重要。SLAM家族的存在拓宽了已知参与免疫调节的受体谱。
