Kwantwi Louis Boafo
Department of Anatomy and Neurobiology, College of Medicine, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.
Clin Transl Oncol. 2025 Mar;27(3):901-908. doi: 10.1007/s12094-024-03675-2. Epub 2024 Aug 30.
Immune cells infiltrating the tumor microenvironment are physiologically important in controlling cancers. However, emerging studies have shown that cancer cells can evade immune surveillance and establish a balance in which these immune cells support tumor progression and therapeutic resistance. The signaling lymphocytic activation molecule family members have been recognized as mediators of tumor microenvironment interactions, and a promising therapeutic target for cancer immunotherapy. This review is focused on the role of SLAM family in tumor and immune cell interactions and discusses how such crosstalk affects tumor behavior. This will shed insight into the next step toward improving cancer immunotherapy.
浸润肿瘤微环境的免疫细胞在控制癌症方面具有重要的生理意义。然而，新出现的研究表明，癌细胞能够逃避免疫监视，并建立一种平衡，在这种平衡中，这些免疫细胞会支持肿瘤进展和治疗抵抗。信号淋巴细胞激活分子家族成员已被公认为肿瘤微环境相互作用的介质，也是癌症免疫治疗的一个有前景的治疗靶点。本综述聚焦于信号淋巴细胞激活分子家族在肿瘤与免疫细胞相互作用中的作用，并讨论这种相互作用如何影响肿瘤行为。这将为改进癌症免疫治疗的下一步研究提供思路。
