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考虑获得性免疫和与受感染水的年龄结构接触模式的血吸虫病传播模型之间的比较。

Comparison between schistosomiasis transmission modelings considering acquired immunity and age-structured contact pattern with infested water.

作者信息

Yang Hyun Mo

机构信息

Universidade Estadual de Campinas, IMECC, Departamento de Matemática Aplicada, Caixa Postal 6065 CEP, Campinas, Sao Paulo 13081-970, Brazil.

出版信息

Math Biosci. 2003 Jul;184(1):1-26. doi: 10.1016/s0025-5564(03)00045-2.

DOI:10.1016/s0025-5564(03)00045-2
PMID:12788231
Abstract

In order to analyze the effects of acquired immunity and the contact pattern with infested water on the overall transmission of schistosomiasis, a semi-stochastic model is proposed. The model's assumptions are the simplest possible to enhance the differences between two hypotheses. With respect to the human host, it is assumed the mounting of an immune response after elapsing a fixed period of time L from the first infection, which is partially effective and never lost. With respect to the contact pattern with infested water, it is assumed a decreasing age-related function. Both models are compared to a purely random model, which is taken as the basic model.

摘要

为了分析获得性免疫以及与受感染水的接触模式对血吸虫病总体传播的影响,提出了一个半随机模型。该模型的假设尽可能简单,以增强两个假设之间的差异。对于人类宿主,假设从首次感染起经过固定时间段L后会产生免疫反应,该免疫反应部分有效且不会丧失。对于与受感染水的接触模式,假设其是与年龄相关的递减函数。将这两个模型与一个纯粹的随机模型进行比较,该随机模型被视为基本模型。

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Math Biosci. 2003 Jul;184(1):1-26. doi: 10.1016/s0025-5564(03)00045-2.
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