Anand Mona, Kumar Rajive, Jain Paresh, Gupta Ritu, Ghosal Nandita, Sharma Atul, Agarwal Amit, Sharma Mehar Chand
Unit of Laboratory Oncology, Institute Rotary Cancer Hospital.
Acta Cytol. 2003 May-Jun;47(3):467-9. doi: 10.1159/000326552.
Anaplastic oligodendroglioma (OG) is an uncommon tumor that rarely metastasizes outside the central nervous system. Spread to the bone marrow (BM) is so rare that when it occurs in the course of follow-up of a case of OG, a disseminated second primary tumor may be a more likely possibility unless BM examination provides evidence to the contrary. Potentially misleading cytologic features of metastatic anaplastic OG can be seen in a BM touch preparation.
A 50-year-old man had undergone left frontal lobectomy in September 1999 for anaplastic OG and presented seven months later with evidence, on BM scan, of focal abnormal uptake at multiple sites. Bone marrow biopsy confirmed OG secondaries, which, on the touch preparation, appeared not only in clusters but also as single cells, simulating acute leukemia.
The morphology of anaplastic OG metastatic to BM simulates acute leukemia, as seen on the BM touch preparation. This is relevant particularly in the context of anaplastic OG on follow-up. This diagnostic pitfall can be heightened if a BM aspirate rather than biopsy is performed. Metastatic OG can be added to the list of tumors that metastasize to BM as single cells.
间变性少突胶质细胞瘤（OG）是一种罕见肿瘤，很少转移至中枢神经系统以外。转移至骨髓（BM）极为罕见，因此在OG病例随访过程中发生这种情况时，除非骨髓检查有相反证据，否则更有可能是播散性第二原发性肿瘤。在骨髓触片标本中可见转移性间变性OG潜在的误导性细胞学特征。
一名50岁男性于1999年9月因间变性OG接受了左额叶切除术，七个月后骨髓扫描显示多个部位有局灶性异常摄取。骨髓活检证实为OG转移灶，在触片标本上，这些转移灶不仅呈簇状出现，还以单个细胞形式存在，类似急性白血病。
骨髓触片标本显示，转移至骨髓的间变性OG形态类似急性白血病。这在间变性OG随访中尤为重要。如果进行骨髓穿刺而非活检，这种诊断陷阱可能会加剧。转移性OG可被列入以单个细胞形式转移至骨髓的肿瘤名单中。
