1p/19q共缺失且异柠檬酸脱氢酶1（IDH1）突变的间变性少突胶质细胞瘤骨转移：一例报告
Bone metastases from a 1p/19q codeleted and IDH1-mutant anaplastic oligodendroglioma: a case report.
作者信息
Burgy Mickaël, Chenard Marie-Pierre, Noël Georges, Bourahla Khalil, Schott Roland
机构信息
Medical Oncology Department, Centre Paul Strauss, 3 Rue de la Porte de l'Hôpital, 67000, Strasbourg, France.
Université de Strasbourg, LBP, CNRS UMR 7213, Illkirch, France.
出版信息
J Med Case Rep. 2019 Jun 28;13(1):202. doi: 10.1186/s13256-019-2061-4.
BACKGROUND
Oligodendroglioma is a rare type of primary brain tumor which, like other malignant gliomas, metastasizes very rarely even when in high-grade form.
CASE REPORT
A 36-year-old white man diagnosed 29 months previously as having 1p/19q codeleted anaplastic oligodendroglioma presented bilateral cruralgia and lower limb motor deficits. A computed tomography scan showed multiple osteoblastic bone lesions. The presence of oligodendroglial cells was revealed by bone marrow biopsy and confirmed by immunohistochemical analyses. A positon emission tomography-computed tomography scan confirmed the exclusive involvement of bones.
CONCLUSION
This case joins less than 20 other reported cases of oligodendroglioma bone marrow metastasis, and is one of only a handful of cases of diffuse bone metastases beyond the axial skeleton. To the best of our knowledge, the early relapse of 1p/19q codeleted anaplastic oligodendroglioma with this distribution of metastases has never been described in the literature.
背景
少突胶质细胞瘤是一种罕见的原发性脑肿瘤，与其他恶性胶质瘤一样，即使处于高级别形式，转移也非常罕见。
病例报告
一名36岁白人男性，29个月前被诊断为1p/19q共缺失间变性少突胶质细胞瘤，出现双侧腿部疼痛和下肢运动功能障碍。计算机断层扫描显示多个成骨性骨病变。骨髓活检发现少突胶质细胞的存在，并经免疫组织化学分析证实。正电子发射断层扫描-计算机断层扫描证实仅骨骼受累。
结论
该病例是其他报道的少于20例少突胶质细胞瘤骨髓转移病例之一，也是少数几例轴外骨骼弥漫性骨转移病例之一。据我们所知，文献中从未描述过1p/19q共缺失间变性少突胶质细胞瘤伴有这种转移分布的早期复发情况。
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