肾原始神经外胚层肿瘤。两例经细针穿刺细胞学诊断的病例报告。

Primitive neuroectodermal tumor of the kidney. A report of two cases diagnosed by fine needle aspiration cytology.

作者信息

Premalata Chennagiri S, Gayathri Devi Muniyappa, Biswas Siddarth, Mukherjee Geethashree, Balu Sadashivan, Sundareshan Tambarahalli S, Prabhakaran Ponnuswamy S

机构信息

Cytopathology Unit, Department of Pathology, Kidwai Memorial Institute of Oncology, M. H. Marigowda Road, Bangalore, India 560029.

出版信息

Acta Cytol. 2003 May-Jun;47(3):475-9. doi: 10.1159/000326554.

DOI:10.1159/000326554

PMID:12789935

Abstract

BACKGROUND

Primitive neurocetodermal tumors (PNETs) constitute a family of neoplasms of presumed neuroectrodermal origin most often presenting as bone or soft tissue masses. There are very few reported cases of PNET of the kidney and none diagnosed by fine needle aspiration cytology (FNAC), to the best of our knowledge, in the world literature. We present two cases of renal PNET diagnosed on cytology.

CASES

Two patients with renal masses were diagnosed as having PNET on FNAC. Cytologically the tumors showed a dispersed population of malignant small round cells with focal rosette formation and perivascular arrangement of tumor cells. Immunohistochemistry on the cell blocks in both cases showed strong membrane positivity for CD99 (MIC2). Cytogenetic studies in both cases showed the characteristic t(11;22)(q24;q12) translocation, with additional chromosomal abnormalities in case 2.

CONCLUSION

PNET of the kidney is a distinct entity and can be diagnosed on fine needle aspiration smears and confirmed with immunohistochemistry and cytogenetic studies. A diagnosis of PNET must be included in the differential diagnosis of renal masses in adolescents and young adults.

摘要